Pharmacists should be aware that cephalosporin cross-reactivity in a penicillin-allergic.
Piperacillin-tazobactam – Similarly, allergic reaction specific to tazobactam is rare but possible. penicillins and cephalosporins is lower than historically reported. Consider penicillin skin-testing +/- amoxicillin challenge. Cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients: Two systematic reviews and meta-analyses. This potential cross-reactivity has extremely important therapeutic implications because many serious infections are best treated with cephalosporins as first-line therapy. Amoxicillin–clavulanate – patients who have a true IgE-mediated hypersensitivity to this drug combination may have an allergy to the clavulanate component, but not amoxicillin or other beta-lactam antibiotics. The 3 Cs of antibiotic allergy-classification, cross-reactivity, and collaboration. It is commonly taught that at least 10 of patients who are allergic to penicillin will have an adverse reaction to cephalosporins. In these patients, use clinical judgement and caution when prescribing any new antimicrobial. NB: Be aware that some patients may react to other β-lactams not because of cross-reactivity but because of their underlying predisposition to develop allergic reactions to multiple unrelated drugs (multiple drug allergy syndrome). drug rash with eosinophilia & systemic symptoms (DRESS) munologic cross-reactivity because penicillin-allergic patients have an increased incidence of hypersensitivity reactions to drugs immunologically unrelated.Avoid all β-lactam antibiotics if documented severe non-lgE-mediated reaction to penicillin:
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